PDGF Receptor beta (PDGFRB) (NM_002609) Human Untagged Clone
SKU
SC309979
PDGFRB (untagged)-Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB)
$1,445.00
In Stock*
Specifications
| Product Data | |
| Type | Human Untagged Clone |
|---|---|
| Target Symbol | PDGF Receptor beta |
| Synonyms | CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PENTT |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data | |
| Restriction Sites | Please inquire | |
| ACCN | NM_002609 |
| Insert Size | 5700 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | There is 1 nucleotide difference between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 1 amino acids. |
| Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution Method | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NM_002609.3, NP_002600.1 |
| RefSeq Size | 5718 bp |
| RefSeq ORF | 3321 bp |
| Locus ID | 5159 |
| UniProt ID | P09619 |
| Cytogenetics | 5q32 |
| Domains | ig, IG, IGc2, pkinase, S_TKc, TyrKc |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Calcium signaling pathway, Colorectal cancer, Cytokine-cytokine receptor interaction, Focal adhesion, Gap junction, Glioma, MAPK signaling pathway, Melanoma, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton |
| Summary | The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia. provided by RefSeq, Aug 2017 |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
"NM_002609" in other vectors (7)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| RC206377 | PDGFRB (Myc-DDK-tagged)-Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) | 10 ug |
$1,444.00
|
|
| RC206377L1 | Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), Myc-DDK-tagged | 10 ug |
$1,744.00
|
|
| RC206377L2 | Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mGFP tagged | 10 ug |
$1,744.00
|
|
| RC206377L3 | Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), Myc-DDK-tagged | 10 ug |
$1,744.00
|
|
| RC206377L4 | Lenti ORF clone of Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB), mGFP tagged | 10 ug |
$1,744.00
|
|
| RC600017 | PDGFRB (DDK-His-tagged)-Extra Cellular Domain Clone of Homo sapiens platelet-derived growth factor receptor, beta polypeptide, Signal peptide (1-32) plus EC domain (33-532) | 10 ug |
$743.00
|
|
| RG206377 | PDGFRB (tGFP-tagged) - Human platelet-derived growth factor receptor, beta polypeptide (PDGFRB) | 10 ug |
$789.00
$1,644.00
|
|
Citations
PNAS Plus: Transposon mutagenesis identifies genes that transform neural stem cells into glioma-initiating cells
Koso, Takeda, Yew et al
PNAS (2012)
Koso, Takeda, Yew et al
PNAS (2012)
Apratoxin a reversibly inhibits the secretory pathway by preventing cotranslational translocation
Liu, Law, Luesch
Mol Pharmacol (2009) 76 (1), 91-104 DOI: 10.1124/mol.109.056085
Liu, Law, Luesch
Mol Pharmacol (2009) 76 (1), 91-104 DOI: 10.1124/mol.109.056085
Cited by 148
AI Summary: In this paper, OriGene products—including the gp130 (IL6ST) and PDGFRB antibodies—were used to detect and analyze the down-regulation of key receptor proteins, helping to demonstrate that apratoxin A inhibits the secretory pathway by preventing cotranslational translocation.
Showing 1-2 of 2 papers.
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