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BCAT1 Human shRNA Plasmid Kit (Locus ID 586)

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SKU
TL314498
BCAT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 586
Synonyms BCATC; BCT1; ECA39; MECA39; PNAS121; PP18
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components BCAT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 586). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC033864, NM_001178091, NM_001178092, NM_001178093, NM_001178094, NM_005504, NM_005504.1, NM_005504.2, NM_005504.3, NM_005504.4, NM_005504.5, NM_005504.6, NM_001178092.1, NM_001178091.1, NM_001178094.1, NM_001178093.1, BC026006, BM458559, NM_001178094.2, NM_001178091.2, NM_005504.7, NM_001178092.2, NM_001178093.2
UniProt ID P54687
Summary This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. provided by RefSeq, May 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway
Kang, Song, Lee et al
Exp Mol Med (2024) 56 (8), 1776-1790 DOI: 10.1038/s12276-024-01286-z
Cited by 38
AI Summary: OriGene’s human shRNA plasmids (Cat# TL314498 for BCATc, TL312348 for HPD, TL304319 for HPDL, and TR30021 for control) were used to silence target genes in human CD4+ memory T cells, enabling the study of how BCAT1-mediated leucine metabolism regulates Th17 responses in this paper.
Snippet: To silence BCATc, HPD, and HPDL expression in human CD4+ memory T cells, we used BCATc, HPD, or HPDL human shRNA plasmids containing the GFP reporter gene (Origene, Rockville, MD;Cat# TL314498 for BCATc, TL312348 for HPD, TL304319 for HPDL, and TR30021 for control). Lentivirus was produced by transfection of the lentiviral vector, along with psPAX2
FigureFigureFigure
Showing 1-1 of 1 papers.
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