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NOTCH1 (NM_017617) Human Recombinant Protein

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SKU
TP762041
Purified recombinant protein of Human notch 1 (NOTCH1),Ala2280-End, with N-terminal His tag, expressed in E. coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Frequently Bought Together (1)

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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region(Ala2280-End) of NOTCH1
Tag N-His
Predicted MW 29 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_060087
Locus ID 4851
UniProt ID P46531
Cytogenetics 9q34.3
RefSeq Size 9312
RefSeq ORF 7668
Synonyms AOS5; AOVD1; hN1; TAN1
Summary This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. provided by RefSeq, Jan 2016
Protein Categories Cancer: Gynecologic, Cancer: Haematopoietic and Lymphoid, CAR-T Targets, Growth Factors, Membrane Proteins
Protein Families Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Stem cell relevant signaling - DSL/Notch pathway
Protein Pathways Dorso-ventral axis formation, Notch signaling pathway, Prion diseases
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Documents
Resources
Other "NOTCH1" proteins (3)
SKU Description Size Price
LC402602 Lyophilized NOTCH1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402602 Transient overexpression lysate of Notch homolog 1, translocation-associated (Drosophila) (NOTCH1) (as WB positive control) 100 ug
$665.00
TP750178 Purified recombinant protein of Human notch 1 (NOTCH1), Glu1448-Gln1734, tag free, expressed in E.Coli, 50 ug 50 ug
$270.00

file-alt Citations

Unbiased cleavage site prediction uncovers viral antagonism of host innate immunity by SARS-CoV-2 3C-like protease
Yucel, Marchiano, Tchelepi et al
JCI Insight (2026) 11 (4) DOI: 10.1172/jci.insight.185739
AI Summary: OriGene contributed the NOTCH1 plasmid (catalog TP762041), which was used in this study to validate predicted host protein cleavage targets of SARS-CoV-2 3CLPro.
Snippet: NOTCH1 (Origene, catalog TP762041), CDH6 (ACROBiosystem, catalog CA6-H5229), and CDH20 (R&D, catalog 5604-CA-050). Purified human α-thrombin was purchased from Haematologic Technologies (catalog 50-883-435)
FigureFigureFigure
Prediction and validation of host cleavage targets of SARS-CoV-2 3C like protease
Yucel, Marchiano, Tchelepi et al
bioRxiv (2022)
Cited by 7
Snippet: : NOTCH1 (Origene, Cat# TP762041),
Showing 1-2 of 2 papers.
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