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PP2A-beta (PPP2CB) (NM_001009552) Human Recombinant Protein

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SKU
TP760699
Purified recombinant protein of Human protein phosphatase 2, catalytic subunit, beta isozyme (PPP2CB), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Frequently Bought Together (1)

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Other products for "PP2A-beta or NM_001009552"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length PPP2CB
Tag N-His
Predicted MW 35.4 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001009552
Locus ID 5516
UniProt ID P62714
Cytogenetics 8p12
RefSeq Size 1987
RefSeq ORF 927
Synonyms PP2Abeta; PP2CB
Summary This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. provided by RefSeq, Mar 2010
Protein Categories Growth Factors, Intracellular Proteins
Protein Families Druggable Genome, Phosphatase
Protein Pathways Long-term depression, Oocyte meiosis, TGF-beta signaling pathway, Tight junction, Wnt signaling pathway
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Other "PP2A-beta" proteins (4)
SKU Description Size Price
LC418183 Lyophilized PPP2CB HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC422909 Lyophilized PPP2CB HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY418183 Transient overexpression lysate of protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform (PPP2CB), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY422909 Transient overexpression lysate of protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform (PPP2CB), transcript variant 2 (as WB positive control) 100 ug
$436.00

file-alt Citations

Dietary potassium stimulates Ppp1Ca-Ppp1r1a dephosphorylation of kidney NaCl co-transporter and reduces blood pressure
Grimm, Tatomir, Rosenbaek et al
J Clin Invest (2023) 133 (21) DOI: 10.1172/JCI158498
AI Summary: In this study, OriGene’s recombinant PP2A (Cat# TP760699) and calcineurin (PPP3CA, Cat# TP762295) proteins were used in GST-pulldown assays to investigate phosphatase interactions with the kidney NaCl co-transporter, contributing to the understanding of how dietary potassium regulates blood pressure.
Snippet: … For GST-pulldown studies, 5 mg GST-(N) NCC or GST protein alone was combined with 2–10 μg recombinant α catalytic subunit of rabbit protein phosphatase 1 (Ppp1ca, MilliporeSigma, P7937), PP2A (Origene, catalog TP760699), or calcineurin (PPP3CA Origene, catalog TP762295) reconstituted in a solution of 250 mM NaCl, 50 mM imidazole, pH 7.4, 2 mM DTT, 1 mM EDTA, 2 mM MnCl2, 0.025 % Tween 20, 10;For GST-pulldown studies, 5 mg of GST-(N) NCC or GST-protein alone was combined with 2-10 ug of recombinant a) alpha catalytic subunit of rabbit protein phosphatase-1 (Ppp1ca, Sigma (P7937), b) PP2A (Origene, Cat# TP760699) or c) calcineurin:
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