TNF alpha (TNF) Human Recombinant Protein
![Figure 2.ELISA plate pre-coated by 1 μg/ml (100 μl/well) Human TNFa , His tagged protein (TP723983) can bind Anti-TNFa Neutralizing antibody (getskuurl sku"TA421243"]) in a linear range of 0.64-16 ng/ml.](https://cdn.origene.com/catalog/product/assets/images/proteins/152/tp723983-2-e.png?width=700&height=700&store=america&image-type=image "Figure 2.ELISA plate pre-coated by 1 μg/ml (100 μl/well) Human TNFa , His tagged protein (TP723983) can bind Anti-TNFa Neutralizing antibody (getskuurl sku\"TA421243\"]) in a linear range of 0.64-16 ng/ml.")
$855.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-6×His Tag |
| Predicted MW | The protein has a predicted molecular mass of 18.1 kDa after removal of the signal peptide. |
| Purity | The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining. |
| Buffer | Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization |
| Reconstitution Method | 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube. 2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000 3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL) 4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample. |
| Preparation | Affinity purification |
| Storage | Store the lyophilized protein at -20°C. After reconstitution, store the protein at -80°C for 12 months. Avoid repeated freezing and thawing. |
| Stability | 12 months from date of despatch |
| Shipping | Ambient |
| Reference Data | |
| Locus ID | 7124 |
| UniProt ID | P01375 |
| Synonyms | DIF;TNF-alpha;TNFA;TNFSF2;cachexin;cachectin;TNFα |
| Summary | This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
| Protein Categories | ADC Targets, Allergies and autoimmune diseases, Chemokines, Cytokines, Growth Factors, Intracellular Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein, Transcription Factors, Transmembrane |
| Protein Pathways | Adipocytokine signaling pathway, Allograft rejection, Alzheimer's disease, Amyotrophic lateral sclerosis (ALS), Apoptosis, Asthma, Cytokine-cytokine receptor interaction, Dilated cardiomyopathy, Fc epsilon RI signaling pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), MAPK signaling pathway, Natural killer cell mediated cytotoxicity, NOD-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Systemic lupus erythematosus, T cell receptor signaling pathway, TGF-beta signaling pathway, Toll-like receptor signaling pathway, Type I diabetes mellitus, Type II diabetes mellitus |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "TNF alpha" proteins (11)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH306983 | TNF MS Standard C13 and N15-labeled recombinant protein (NP_000585) | 10 ug |
$3,360.00
|
|
| LC424626 | Lyophilized TNF HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY424626 | Transient overexpression lysate of tumor necrosis factor (TNF superfamily, member 2) (TNF) (as WB positive control) | 100 ug |
$436.00
|
|
| TP306983 | Recombinant protein of human tumor necrosis factor (TNF superfamily, member 2) (TNF), 20 µg | 20 ug |
$737.00
|
|
| TP700015 | Recombinant protein of human soluble form of TNF-alpha with His and DDK tags, expressed in human cells | 20 ug |
$900.00
|
|
| TP720007 | Recombinant protein of human tumor necrosis factor (TNF superfamily, member 2) (TNF), the soluble form (Val77 -Leu233) | 10 ug |
$205.00
|
|
| TP721024 | Purified recombinant protein of Human tumor necrosis factor (TNF) | 10 ug |
$180.00
|
|
| TP721025 | Purified recombinant protein of Human tumor necrosis factor (TNF) | 10 ug |
$340.00
|
|
| TP723708 | Purified recombinant protein of Human tumor necrosis factor (TNF) | 10 ug |
$345.00
|
|
| TP750007 | Recombinant protein of human Tumor Necrosis Factor-a (TNFa) produced in E. coli. | 100 ug |
$540.00
|
|
| TP750117 | Purified recombinant protein of Human tumor necrosis factor (TNF) mutant, tag free, expressed in E.Coli, 50 ug | 50 ug |
$270.00
|
|
Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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