MCSF Receptor (CSF1R) Human Recombinant Protein

SKU TP723975

Human CSF1R Protein, His Tag

Product Data

• Species: Human
• Expression Host: HEK293
• Expression cDNA Clone or AA Sequence:
  Protein Sequence

  CSF1R（Ile20-Leu514）+6×His tag
• Tag: C- 6×His
• Predicted MW: 55.6 kDa
• Purity: > 95%
• Buffer: Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
• Reconstitution Method: Reconstitute with deionized water
• Preparation: Affinity purification
• Storage: Store the lyophilized protein at -20°C.; After reconstitution, store the protein at -80°C for 12 months.; Avoid repeated freezing and thawing.
• Stability: 12 months from date of despatch
• Shipping: Ambient

Reference Data

• Locus ID: 1436
• UniProt ID: P07333
• Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Alternative splicing results in multiple transcript variants. Expression of a splice variant from an LTR promoter has been found in Hodgkin lymphoma (HL), HL cell lines and anaplastic large cell lymphoma.
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Endocytosis, Hematopoietic cell lineage, Pathways in cancer