IL6 (NM_000600) Human Recombinant Protein

CAT#: TP723713

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Purified recombinant protein of Human interleukin 6 (interferon, beta 2) (IL6)


Product Datasheet for 'TP723713'


  View other "IL6" proteins (7)

USD 205.00


Availability*
2 Weeks

Size
    • 10 ug


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Specifications

Product Data
Description Purified recombinant protein of Human interleukin 6 (interferon, beta 2) (IL6)
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence Human IL-6, the region of Pro29-Met212, from gene Accession# NM_000600
Tag Tag Free
Predicted MW 21 kDa
Concentration Protein formulated and vialed at >50 ug/mL in specified buffer
Purity Purity is >98%, as determined by Coomassie stained SDS-PAGE.
Buffer 10mM NaH2PO4, 150mM NaCl, pH7.2
Bioactivity The ED50 is 4-20 pg/ml, corresponding to a specific activity of 0.5-2.5 X10^8 units/mg, determined by a dose dependent stimulation in a 7TD1 cell proliferation assay.
Endotoxin Less than 0.01 ng per ug protein as determined by the LAL method
Reference Data
RefSeq NP_000591
Locus ID 3569
Refseq Size 1201
Cytogenetics 7p15.3
Refseq ORF 636
Synonyms BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6
Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Cytokine-cytokine receptor interaction, Cytosolic DNA-sensing pathway, Graft-versus-host disease, Hematopoietic cell lineage, Hypertrophic cardiomyopathy (HCM), Jak-STAT signaling pathway, NOD-like receptor signaling pathway, Pathways in cancer, Prion diseases, Toll-like receptor signaling pathway

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Other Versions

Frequently bought together (1)
IL6 mouse monoclonal antibody, clone OTI3G9 (formerly 3G9)
    • 100 ul

USD 379.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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