BMPR2 (NM_001204) Human Recombinant Protein
Recombinant protein of human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)
Product Datasheet for 'TP720272'
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|Description||Recombinant protein of human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)|
|Expression cDNA Clone or AA Sequence||A DNA sequence from TrueORF clone, RC208673, encoding the secreted form (Ser27-Ile151) of human BMPR2|
|Predicted MW||15.0 kDa|
|Concentration||Resuspend the protein to the desired concentration in proper buffer.|
|Purity||>95% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||Lyophilized from a 0.2 µM filtered solution of 20mM Phosphate buffer, 150mM NaCl, pH 7.4. Stable for at least 6 months from date of receipt under proper storage and handling conditions.|
|Endotoxin||< 0.1 EU per µg protein as determined by LAL test|
|Synonyms||BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK|
|Summary||This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, Jul 2008]|
|Protein Families||Protein Kinase, Transmembrane, Druggable Genome|
|Protein Pathways||Cytokine-cytokine receptor interaction, TGF-beta signaling pathway|