YAP1 (NM_001130145) Human Recombinant Protein
SKU
TP325864
Purified recombinant protein of Homo sapiens Yes-associated protein 1, 65kDa (YAP1), transcript variant 1, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 54.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001123617 |
| Locus ID | 10413 |
| UniProt ID | P46937 |
| Cytogenetics | 11q22.1 |
| RefSeq ORF | 1512 |
| Synonyms | COB1; YAP; YAP2; YAP65; YKI |
| Summary | This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Aug 2013 |
| Protein Categories | Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "YAP1" proteins (5)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH325864 | YAP1 MS Standard C13 and N15-labeled recombinant protein (NP_001123617) | 10 ug |
$3,360.00
|
|
| LC401842 | Lyophilized YAP1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC434268 | Lyophilized YAP1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401842 | Transient overexpression lysate of Yes-associated protein 1, 65kDa (YAP1), transcript variant 2 (as WB positive control) | 100 ug |
$665.00
|
|
| LY434268 | Transient overexpression lysate of Yes-associated protein 1 (YAP1), transcript variant 3 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
Type I gamma phosphatidylinositol phosphate kinase i5 suppresses YAP1 signaling
Ghosh, Kakar, Bavuso et al
J Biol Chem (2025)
Ghosh, Kakar, Bavuso et al
J Biol Chem (2025)
Cited by 1
Snippet: YAP1 human recombinant protein (catalog no.: TP325864) was purchased from OriGene. GST-14-3-3 (catalog no.: 10838-H09E) was from Sino Biological. Antibodies to 14-3-3 HRP (catalog no.: sc-1657HRP) and α-Tubulin (catalog no.: sc398103) were from Santa Cruz Biotechnology. Antibodies to YAP1 (catalog no.: 14074S), GST-tag (catalog no.: 2622S), HA-tag (catalog no.: 3724S),
Calmodulin activates the Hippo signaling pathway by promoting LATS1 kinase-mediated inhibitory phosphorylation of the transcriptional coactivator YAP
Thines, Gorisse, Li et al
J Biol Chem (2022) 298 (5), 101839 DOI: 10.1016/j.jbc.2022.101839
Thines, Gorisse, Li et al
J Biol Chem (2022) 298 (5), 101839 DOI: 10.1016/j.jbc.2022.101839
Cited by 14
AI Summary: In this study, OriGene products including the LATS1 (RC210590) and YAP (RC208951) expression plasmids were used to overexpress these proteins in mammalian cells, enabling the investigation of calmodulin’s role in activating the Hippo signaling pathway through LATS1-mediated phosphorylation of YAP.
Snippet: The Hippo signaling pathway regulates tissue growth and cell fate, and its dysregulation can induce tumorigenesis. When Hippo is activated by cell-cell contact, extracellular signals, or cell polarity among others, the large tumor suppressor 1 (LATS1) kinase catalyzes inhibitory phosphorylation of the transcriptional coactivator Yes-associated protein (YAP) to maintain YAP in the cytoplasm or prom...
Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation
Tyra, Nandi, Tracy et al
Dev. Cell (2020) 52 (5), 605-616.e7 DOI: 10.1016/j.devcel.2020.01.011
Tyra, Nandi, Tracy et al
Dev. Cell (2020) 52 (5), 605-616.e7 DOI: 10.1016/j.devcel.2020.01.011
Cited by 25
Protein painting, an optimized MS-based technique, reveals functionally relevant interfaces of the PD-1/PD-L1 complex and the YAP2/ZO-1 complex
Haymond, Dey, Carter et al
J. Biol. Chem. (2019)
Haymond, Dey, Carter et al
J. Biol. Chem. (2019)
Showing 1-4 of 4 papers.
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