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GALE (NM_001127621) Human Recombinant Protein

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SKU
TP325521
Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 3, 20 µg
Size:
20 ug 1 mg 100 ug
  $867.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
>RC225521 protein sequence
Red=Cloning site Green=Tags(s)

MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQ
GALQRLFKKYSFMAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQ
YLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCQADKTWNAVLLRYFNPTGAHASGCIGEDPQGIPNNLMP
YVSQVAIGRREALNVFGNDYDTEDGTGVRDYIHVVDLAKGHIAALRKLKEQCGCRIYNLGTGTGYSVLQM
VQAMEKASGKKIPYKVVARREGDVAACYANPSLAQEELGWTAALGLDRMCEDLWRWQKQNPSGFGTQA

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag C-Myc/DDK
Predicted MW 38.1 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001121093
Locus ID 2582
UniProt ID Q14376
Cytogenetics 1p36.11
RefSeq Size 1626
RefSeq ORF 1044
Synonyms SDR1E1
Summary This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and cognitive disability, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified. provided by RefSeq, Jul 2008
Protein Categories Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Amino sugar and nucleotide sugar metabolism, Galactose metabolism, Metabolic pathways
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Other "GALE" proteins (12)
SKU Description Size Price
PH301561 GALE MS Standard C13 and N15-labeled recombinant protein (NP_000394) 10 ug
$3,360.00
PH308709 GALE MS Standard C13 and N15-labeled recombinant protein (NP_001008217) 10 ug
$3,360.00
PH325521 GALE MS Standard C13 and N15-labeled recombinant protein (NP_001121093) 10 ug
$3,360.00
LC423394 Lyophilized GALE HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC424739 Lyophilized GALE HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426826 Lyophilized GALE HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY423394 Transient overexpression lysate of UDP-galactose-4-epimerase (GALE), transcript variant 2 (as WB positive control) 100 ug
$436.00
LY424739 Transient overexpression lysate of UDP-galactose-4-epimerase (GALE), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY426826 Transient overexpression lysate of UDP-galactose-4-epimerase (GALE), transcript variant 3 (as WB positive control) 100 ug
$436.00
TP301561 Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 1, 20 µg 20 ug
$867.00
TP308709 Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 2, 20 µg 20 ug
$867.00
TP720236 Recombinant protein of human UDP-galactose-4-epimerase (GALE), transcript variant 1 10 ug
$340.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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