CTBP2 (NM_001329) Human Recombinant Protein

Specifications

Product Data
Description	Recombinant protein of human C-terminal binding protein 2 (CTBP2), transcript variant 1
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	Recombinant protein was produced with TrueORF clone, RC224861. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag	C-MYC/DDK
Predicted MW	48.8 kDa
Concentration	>50 ug/mL as determined by microplate BCA method
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer	25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Reference Data
RefSeq	NP_001320
Locus ID	1488
Refseq Size	2368
Cytogenetics	10q26.13
Refseq ORF	1335
Synonyms	OTTHUMP00000020699; OTTHUMP00000020701; ribeye; C-terminal binding protein 2
Summary	This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Protein Families	Stem cell relevant signaling - Wnt Signaling pathway, Stem cell - Pluripotency
Protein Pathways	Wnt signaling pathway, Notch signaling pathway, Pathways in cancer, Chronic myeloid leukemia

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