POLR2J2 (NM_032959) Human Recombinant Protein

CAT#: TP324755

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Recombinant protein of human polymerase (RNA) II (DNA directed) polypeptide J2 (POLR2J2)


 Product Datasheet for 'TP324755'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human polymerase (RNA) II (DNA directed) polypeptide J2 (POLR2J2)
Species Human
Expression Host HEK293T
Tag C-Myc/DDK
Predicted MW 12.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_116581
Locus ID 246721
Refseq Size 1727
Cytogenetics 7q22.1
Refseq ORF 345
Synonyms HRPB11B; POLR2J3; RPB11b1; RPB11b2
Summary This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]
Protein Families Transcription Factors
Protein Pathways Huntington's disease, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase

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