E Cadherin (CDH1) (NM_004360) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 94.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004351 |
| Locus ID | 999 |
| UniProt ID | P12830 |
| Cytogenetics | 16q22.1 |
| RefSeq Size | 4828 |
| RefSeq ORF | 2646 |
| Synonyms | Arc-1; BCDS1; CD324; CDHE; ECAD; LCAM; UVO |
| Summary | This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. provided by RefSeq, Nov 2015 |
| Protein Categories | Cancer: Endocrine, Cancer: Gastrointestinal, Cancer: Gynecologic, Cancer: Head and Neck, CD Markers, Membrane Proteins |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Adherens junction, Bladder cancer, Cell adhesion molecules (CAMs), Endometrial cancer, Melanoma, Pathogenic Escherichia coli infection, Pathways in cancer, Thyroid cancer |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "E Cadherin" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH320731 | CDH1 MS Standard C13 and N15-labeled recombinant protein (NP_004351) | 10 ug |
$3,360.00
|
|
| LC401389 | Lyophilized CDH1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401389 | Transient overexpression lysate of cadherin 1, type 1, E-cadherin (epithelial) (CDH1) (as WB positive control) | 100 ug |
$665.00
|
|
Citations
Paeoniflorin inhibits epithelial mesenchymal transformation and oxidative damage of lens epithelial cells in diabetic cataract via sirtuin 1 upregulation
Zeng, Xi, Qiao et al
Bioengineered (2022) 13 (3), 5903-5914 DOI: 10.1080/21655979.2021.2018534
Zeng, Xi, Qiao et al
Bioengineered (2022) 13 (3), 5903-5914 DOI: 10.1080/21655979.2021.2018534
Cited by 14
AI Summary: OriGene’s E-cadherin antibody (OriGene Technologies, Inc.) was used in this study to assess protein expression changes during epithelial-mesenchymal transition in lens epithelial cells, contributing to the investigation of paeoniflorin’s protective effects in diabetic cataract.
Snippet: eins were subsequently transferred to a PVDF membrane and blocked with skimmed milk powder for 1.5 h. The membranes were incubated with the following primary antibodies against: E-cadherin (1:1,000;Origene Technologies, Inc.), N-cadherin (1:1,000;Cell Signaling Technology, Inc.), Vimentin (1:1,000;Cell Signaling Technology, Inc.), Snail (1:1,000;Abcam), Bax (1:1,000;Abcam), cleaved (c)-caspa
Synergistic antitumor activity of aspirin and erlotinib: Inhibition of p38 enhanced aspirin plus erlotinib-induced suppression of metastasis and promoted cancer cell apoptosis
Hu, Wu, Weng et al
Oncol Lett (2018) 16 (2), 2715-2724 DOI: 10.3892/ol.2018.8956
Hu, Wu, Weng et al
Oncol Lett (2018) 16 (2), 2715-2724 DOI: 10.3892/ol.2018.8956
AI Summary: In this study, the OriGene E-cadherin plasmid (RG220731) was used to investigate the role of E-cadherin in mediating the synergistic antitumor effects of aspirin and erlotinib on cancer cell apoptosis and metastasis.
Snippet: E-cadherin (RG220731;Origene Technologies, Rockville, MD, USA) and empty vector plasmid were trans- fected into cells using Lipofectamine 3000 (Invitrogen;Thermo Fisher Scientific, Inc., Waltham, MA, USA) according to the manufacturer's instructions. siRNA transfection
Showing 1-2 of 2 papers.
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