FAK (PTK2) (NM_153831) Human Recombinant Protein
SKU
TP319839
Recombinant protein of human PTK2 protein tyrosine kinase 2 (PTK2), transcript variant 1, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 119.1 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_722560 |
| Locus ID | 5747 |
| UniProt ID | Q05397 |
| Cytogenetics | 8q24.3 |
| RefSeq Size | 4453 |
| RefSeq ORF | 3165 |
| Synonyms | FADK; FADK 1; FAK; FAK1; FRNK; p125FAK; pp125FAK; PPP1R71 |
| Summary | This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jun 2017 |
| Protein Categories | Enzyme: Kinases, Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Axon guidance, Chemokine signaling pathway, ErbB signaling pathway, Focal adhesion, Leukocyte transendothelial migration, Pathways in cancer, Regulation of actin cytoskeleton, Small cell lung cancer, VEGF signaling pathway |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "FAK" proteins (9)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH319839 | PTK2 MS Standard C13 and N15-labeled recombinant protein (NP_722560) | 10 ug |
$3,360.00
|
|
| PH321398 | PTK2 MS Standard C13 and N15-labeled recombinant protein (NP_005598) | 10 ug |
$3,360.00
|
|
| LC403521 | Lyophilized PTK2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC417186 | Lyophilized PTK2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC429259 | Lyophilized PTK2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY403521 | Transient overexpression lysate of PTK2 protein tyrosine kinase 2 (PTK2), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| LY417186 | Transient overexpression lysate of PTK2 protein tyrosine kinase 2 (PTK2), transcript variant 2 (as WB positive control) | 100 ug |
$665.00
|
|
| LY429259 | Transient overexpression lysate of PTK2 protein tyrosine kinase 2 (PTK2), transcript variant 2 (as WB positive control) | 100 ug |
$665.00
|
|
| TP321398 | Recombinant protein of human PTK2 protein tyrosine kinase 2 (PTK2), transcript variant 2, 20 µg | 20 ug |
$867.00
|
|
Citations
Intracellular HMGB1 negatively regulates efferocytosis
Banerjee, de Freitas, Friggeri et al
J. Immunol. (2011) 187 (9), 4686-94 DOI: 10.4049/jimmunol.1101500
Banerjee, de Freitas, Friggeri et al
J. Immunol. (2011) 187 (9), 4686-94 DOI: 10.4049/jimmunol.1101500
Cited by 69
AI Summary: OriGene’s recombinant FAK1 Myc protein was used in in vitro experiments to investigate how HMGB1 affects the interaction between FAK and Src, thereby contributing to the study’s findings on the regulation of phagocytosis by intracellular HMGB1.
Snippet: In vitro GST pull down. Flag-tagged HMGB1 protein was purified from an HEK 293T cell line that stably expressed HMGB1-Flag, as described previously (17). Recombinant FAK1 Myc protein (OriGene Technologies) and Src-GST (Sino Biological) were obtained commercially.
Showing 1-1 of 1 papers.
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