MYBPC3 (NM_000256) Human Recombinant Protein

CAT#: TP317720

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Purified recombinant protein of Homo sapiens myosin binding protein C, cardiac (MYBPC3)



  View other "MYBPC3" proteins (3)

USD 788.00


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Size
    • 20 ug


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Specifications

Product Data
Description Purified recombinant protein of Homo sapiens myosin binding protein C, cardiac (MYBPC3)
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC217720. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-Myc/DDK
Predicted MW 140.6 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000247
Locus ID 4607
Refseq Size 4200
Cytogenetics 11p11.2
Refseq ORF 3822
Synonyms CMD1MM; CMH4; FHC; LVNC10; MYBP-C
Summary MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM)

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