MYBPC3 Mouse Monoclonal Antibody [Clone ID: OTI1D1]
Specifications
| Product Data | |
| Clone Name | OTI1D1 |
|---|---|
| Application | ELISA |
| Recommended Dilution | ELISA 1:5000-10000 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human MYBPC3(C0-C1) (NP_000247) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Shipping | Blue Ice |
| Predicted Protein Size | 140.8 kDa |
| Gene Name | myosin binding protein C, cardiac |
| Database Link | |
| Background | MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3, the cardiac isoform, is expressed exclussively in heart muscle. Regulatory phosphorylation of the cardiac isoform in vivo by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction. Mutations in MYBPC3 are one cause of familial hypertrophic cardiomyopathy. provided by RefSeq, Jul 2008 |
| Synonyms | CMD1MM; CMH4; cMyBP-C; FHC; LVNC10; MYBP-C |
| Reference Data | |
| Protein Categories | Cardiovascular diseases, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
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