SIN1 (MAPKAP1) (NM_001006617) Human Recombinant Protein
SKU
TP311745
Purified recombinant protein of Human mitogen-activated protein kinase associated protein 1 (MAPKAP1), transcript variant 1, full length, with C-terminal MYC/DDK tag, expressed in HEK293 cells, 20 µg
$867.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 58.9 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_001006618 |
| Locus ID | 79109 |
| UniProt ID | Q9BPZ7 |
| Cytogenetics | 9q33.3 |
| RefSeq Size | 3395 |
| RefSeq ORF | 1566 |
| Synonyms | JC310; MIP1; SIN1; SIN1b; SIN1g |
| Summary | This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been described. Alternate polyadenylation sites as well as alternate 3' UTRs have been identified for transcripts of this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome |
Reviews
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| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "SIN1" proteins (9)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH311745 | MAPKAP1 MS Standard C13 and N15-labeled recombinant protein (NP_001006618) | 10 ug |
$3,360.00
|
|
| LC400381 | Lyophilized MAPKAP1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC411350 | Lyophilized MAPKAP1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC423519 | Lyophilized MAPKAP1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC423693 | Lyophilized MAPKAP1 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400381 | Transient overexpression lysate of mitogen-activated protein kinase associated protein 1 (MAPKAP1), transcript variant 6 (as WB positive control) | 100 ug |
$436.00
|
|
| LY411350 | Transient overexpression lysate of mitogen-activated protein kinase associated protein 1 (MAPKAP1), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| LY423519 | Transient overexpression lysate of mitogen-activated protein kinase associated protein 1 (MAPKAP1), transcript variant 5 (as WB positive control) | 100 ug |
$436.00
|
|
| LY423693 | Transient overexpression lysate of mitogen-activated protein kinase associated protein 1 (MAPKAP1), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
Citations
A p53-phosphoinositide signalosome regulates nuclear AKT activation
Chen, Choi, Wen et al
Nat Cell Biol (2022) 24 (7), 1099-1113 DOI: 10.1038/s41556-022-00949-1
Chen, Choi, Wen et al
Nat Cell Biol (2022) 24 (7), 1099-1113 DOI: 10.1038/s41556-022-00949-1
Cited by 120
AI Summary: In this study, OriGene’s p53 expression plasmids (Cat# RC200003 and RC200004) and shRNA plasmids (Cat# TG313295 and TG313296) were used to manipulate p53 levels, enabling the authors to investigate how p53 regulates nuclear AKT activation in response to genotoxic stress.
Snippet: its survival, proliferative and oncogenic roles in cancer. Consistent with this idea, knock-in of mutant p53 in mice leads to elevated Akt signaling and tumorigenesis61 and expression levels of p53, a surrogate marker for p53 mutational status62, 63, correlate with active Akt in human colorectal carcinomas64
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2
Kovalski, Bhaduri, Zehnder et al
Mol. Cell (2019) 73 (4), 830-844.e12 DOI: 10.1016/j.molcel.2018.12.001
Kovalski, Bhaduri, Zehnder et al
Mol. Cell (2019) 73 (4), 830-844.e12 DOI: 10.1016/j.molcel.2018.12.001
AI Summary: In this study, OriGene’s recombinant proteins—including NRASQ61K (Cat# TP701004), NRAS (Cat# TP302681), MAPKAP1 (Cat# TP311745), mTOR (Cat# TP320457), KRASG12D (Cat# TP700052), HRASWT (Cat# TP316409), and custom-produced HRASG12V—were used to investigate and validate the interactions between oncogenic Ras proteins and mTORC2 components, elucidating key mechanisms in Ras-driven cancer proliferation.
Snippet: … They demonstrate that active Ras binds and stimulates mTORC2, representing a key dependency for Ras-driven proliferation genes and tumorigenesis. Cancer Ras Proteomics CRISPR mTOR MAPKAP1;... … They demonstrate that active Ras binds and stimulates mTORC2, representing a key dependency for Ras-driven proliferation genes and tumorigenesis. Cancer Ras Proteomics CRISPR mTOR MAPKAP1;NRASQ61K Human Recombinant Protein Origene Cat# TP701004 NRAS Human Recombinant Protein Origene Cat# TP302681 MAPKAP1 Human Recombinant Protein Origene Cat# TP311745 mTOR Human Recombinant Protein Origene Cat# TP320457 KRASG12D Human Recombinant Protein Origene Cat# TP700052 HRASWT Human Recombinant Protein Origene Cat# TP316409 HRASG12V Human Recombinant Protein Origene Custom Production from clone Cat# RC400129
Showing 1-2 of 2 papers.
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