EGLN2 (NM_053046) Human Recombinant Protein
SKU
TP306152
Recombinant protein of human egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 43.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Enzyme activity (In vitro hydroxylation assay) (PMID: 26751287) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_444274 |
| Locus ID | 112398 |
| UniProt ID | Q96KS0 |
| Cytogenetics | 19q13.2 |
| RefSeq Size | 2264 |
| RefSeq ORF | 1221 |
| Synonyms | EIT-6; EIT6; HIF-PH1; HIFPH1; HPH-1; HPH-3; PHD1 |
| Summary | The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. provided by RefSeq, Feb 2011 |
| Protein Categories | Growth Factors, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Pathways in cancer, Renal cell carcinoma |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "EGLN2" proteins (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH306152 | EGLN2 MS Standard C13 and N15-labeled recombinant protein (NP_444274) | 10 ug |
$3,360.00
|
|
| LC403281 | Lyophilized EGLN2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC409048 | Lyophilized EGLN2 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY403281 | Transient overexpression lysate of egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| LY409048 | Transient overexpression lysate of egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 3 (as WB positive control) | 100 ug |
$436.00
|
|
| TP760370 | Purified recombinant protein of Human egl nine homolog 2 (C. elegans) (EGLN2), transcript variant 3, with N-terminal HIS tag, expressed in E.Coli, 50ug | 50 ug |
$270.00
|
|
Citations
Proline Hydroxylation Primes Protein Kinases for Autophosphorylation and Activation
Lee, Ko, Oh et al
Mol. Cell (2020) 79 (3), 376-389.e8 DOI: 10.1016/j.molcel.2020.06.021
Lee, Ko, Oh et al
Mol. Cell (2020) 79 (3), 376-389.e8 DOI: 10.1016/j.molcel.2020.06.021
Cited by 38
AI Summary: OriGene’s insulin cDNA clone was used as a template for PCR amplification and subsequent cloning into a yeast vector, enabling functional studies described in the paper.
Snippet: We procured a cDNA clone of insulin from Origene Inc., USA. Insulin cDNA was PCR amplified and cloned into yeast vector pPICZ-α
The LINK-A lncRNA activates normoxic HIF1 [alpha] signalling in triple-negative breast cancer
Lin, Li, Xing et al
Nature cell biology (2016)
Lin, Li, Xing et al
Nature cell biology (2016)
Snippet: Yang and colleagues identify a lncRNA that controls HIF1[alpha] signalling to stabilize HIF1[alpha] under normoxic conditions, and promotes breast cancer tumorigenesis. Cite SaveSaving
Showing 1-2 of 2 papers.
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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