NEU4 (NM_080741) Human Recombinant Protein
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 52.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Bioactivity | Cell treatment (PMID: 29118338) |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_542779 |
| Locus ID | 129807 |
| UniProt ID | Q8WWR8 |
| Cytogenetics | 2q37.3 |
| RefSeq Size | 2373 |
| RefSeq ORF | 1488 |
| Summary | The protein encoded by this gene belongs to a family of glycohydrolytic enzymes, which remove terminal sialic acid residues from various sialo derivatives, such as glycoproteins, glycolipids, oligosaccharides, and gangliosides. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. provided by RefSeq, Nov 2009 |
| Protein Categories | Intracellular Proteins |
| Protein Pathways | Other glycan degradation, Sphingolipid metabolism |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "NEU4" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH303948 | NEU4 MS Standard C13 and N15-labeled recombinant protein (NP_542779) | 10 ug |
$3,360.00
|
|
| LC409058 | Lyophilized NEU4 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY409058 | Transient overexpression lysate of sialidase 4 (NEU4), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
Citations
The extracellular sialidase NEU3 primes neutrophils
Kirolos, Pilling, Gomer
J Leukoc Biol (2022)
Kirolos, Pilling, Gomer
J Leukoc Biol (2022)
Attenuated pulmonary fibrosis in sialidase-3 knockout (Neu3-/-) mice
Karhadkar, Chen, Gomer
Am J Physiol Lung Cell Mol Physiol (2020) 318 (1), L165-L179 DOI: 10.1152/ajplung.00275.2019
Karhadkar, Chen, Gomer
Am J Physiol Lung Cell Mol Physiol (2020) 318 (1), L165-L179 DOI: 10.1152/ajplung.00275.2019
Cited by 34
Sialidase inhibitors attenuate pulmonary fibrosis in a mouse model
Karhadkar, Pilling, Cox et al
Sci Rep (2017) 7 (1), 15069 DOI: 10.1038/s41598-017-15198-8
Karhadkar, Pilling, Cox et al
Sci Rep (2017) 7 (1), 15069 DOI: 10.1038/s41598-017-15198-8
AI Summary: In this study, OriGene’s recombinant human NEU1, NEU2, NEU3, and NEU4 proteins were used to investigate the effects of sialidases on immune cell activity and fibrosis development in vitro.
Snippet: Where indicated, recombinant 10 ng/ml human TGF-β1 (Peprotech, Rocky Hill, NJ), 200 ng/ml recombinant human NEU1, 2, 3, or 4 (Origene, Rockville, MD), or 2 µg/ml human SAP (EMD Millipore, Billerica, MA;with the azide removed by centrifugal filters following86) were added to cells. Fibrocytes were counted as previously described29,84
Showing 1-3 of 3 papers.
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