BCCIP (NM_078468) Human Recombinant Protein
SKU
TP303061M
Recombinant protein of human BRCA2 and CDKN1A interacting protein (BCCIP), transcript variant B, 100 µg
$2,508.00
4 Weeks*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 35.8 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_510868 |
| Locus ID | 56647 |
| UniProt ID | Q9P287 |
| Cytogenetics | 10q26.2 |
| RefSeq Size | 1261 |
| RefSeq ORF | 942 |
| Synonyms | TOK-1; TOK1 |
| Summary | This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins |
| Protein Families | Druggable Genome, Stem cell - Pluripotency |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Citations
Efficient embryonic homozygous gene conversion via RAD51-enhanced interhomolog repair
Wilde, Aida, Del Rosario et al
Cell (2021) 184 (12), 3267-3280.e18 DOI: 10.1016/j.cell.2021.04.035
Wilde, Aida, Del Rosario et al
Cell (2021) 184 (12), 3267-3280.e18 DOI: 10.1016/j.cell.2021.04.035
Cited by 95
AI Summary: In this study, OriGene's BCCIP (TP303061) and XRCC1 (TP304952) human recombinant proteins were used to investigate factors that promote interhomolog repair and enhance gene conversion efficiency in mouse embryos.
Snippet: Recombinant Human USP1&WDR48 Protein, His-tagged, Creative Biomart, USP1&WDR48-1067H. BCCIP (NM_078468) Human Recombinant Protein, Origene, TP303061. XRCC1 (NM_006297) Human Recombinant Protein, Origene, TP304952. Deposited data;BCCIP (NM_078468) Human Recombinant Protein Origene TP303061 XRCC1 (NM_006297) Human Recombinant Protein Origene TP304952
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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