KREMEN2 (NM_024507) Human Recombinant Protein
Recombinant protein of human kringle containing transmembrane protein 2 (KREMEN2), transcript variant 2
Product Datasheet for 'TP302558'
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|Description||Recombinant protein of human kringle containing transmembrane protein 2 (KREMEN2), transcript variant 2|
|Expression cDNA Clone or AA Sequence||Recombinant protein was produced with TrueORF clone, RC202558. Click on the TrueORF clone link to view cDNA and protein sequences.|
|Predicted MW||42.3 kDa|
|Concentration||>50 ug/mL as determined by microplate BCA method|
|Purity||> 80% as determined by SDS-PAGE and Coomassie blue staining|
|Buffer||25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol|
|Preparation||Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.|
|Summary||This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]|
|Protein Families||Druggable Genome, Transmembrane|
|PH302558||KREMEN2 MS Standard C13 and N15-labeled recombinant protein (NP_078783)||
|LY402993||Transient overexpression lysate of kringle containing transmembrane protein 2 (KREMEN2), transcript variant 2||
|LC402993||KREMEN2 HEK293T cell transient overexpression lysate (as WB positive control)||