KREMEN2 (NM_024507) Human Recombinant Protein

CAT#: TP302558

Recombinant protein of human kringle containing transmembrane protein 2 (KREMEN2), transcript variant 2


 Product Datasheet for 'TP302558'

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USD 748.00


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Size
    • 20 ug


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Specifications

Product Data
Description Recombinant protein of human kringle containing transmembrane protein 2 (KREMEN2), transcript variant 2
Species Human
Expression Host HEK293T
Expression cDNA Clone or AA Sequence Recombinant protein was produced with TrueORF clone, RC202558. Click on the TrueORF clone link to view cDNA and protein sequences.
Tag C-MYC/DDK
Predicted MW 42.3 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. Store at –80C. Avoid repeated freeze-thaw cycles. Stable for 3 months from receipt of products under proper storage and handling conditions.
Preparation Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Reference Data
RefSeq NP_078783
Locus ID 79412
Refseq Size 1989
Cytogenetics 16p13.3
Refseq ORF 1263
Synonyms KRM2; KRM2
Summary This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Protein Families Transmembrane, Druggable Genome

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Other Versions

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