RAB7 (RAB7A) (NM_004637) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 23.3 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_004628 |
| Locus ID | 7879 |
| UniProt ID | P51149 |
| Cytogenetics | 3q21.3 |
| RefSeq Size | 2240 |
| RefSeq ORF | 621 |
| Synonyms | CMT2B; PRO2706; RAB7 |
| Summary | RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. provided by RefSeq, Jul 2008 |
| Protein Categories | Growth Factors, Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Druggable Genome |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "RAB7" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301776 | RAB7A MS Standard C13 and N15-labeled recombinant protein (NP_004628) | 10 ug |
$3,360.00
|
|
| LC417854 | Lyophilized RAB7A HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY417854 | Transient overexpression lysate of RAB7A, member RAS oncogene family (RAB7A) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation
Pavel, Park, Frake et al
Nat Commun (2021) 12 (1), 1703 DOI: 10.1038/s41467-021-21882-1
Pavel, Park, Frake et al
Nat Commun (2021) 12 (1), 1703 DOI: 10.1038/s41467-021-21882-1
Cited by 32
AI Summary: OriGene’s CTNNA1 protein (TP301776) was used in protein binding assays to investigate interactions with LC3B, helping to elucidate the molecular mechanisms underlying the regulation of YAP/TAZ signaling by autophagy and α-catenin levels in this study.
Snippet: …Protein binding assay Binding of LC3B (purified from E. coli) to CTNNA1 (TP301776, Origene) was performed by incubation of recombinant proteins at 25 °C for 1 h, followed by immunoprecipitation with rabbit anti-CTNNA1 antibody (ab51032, Abcam, 1:100) and processed for WB analys;Binding of LC3B (purified from E. coli) to CTNNA1 (TP301776, Origene) was performed by incubation of recombinant proteins at 25 °C for 1 h, followed by immunoprecipitation with rabbit anti-CTNNA1 antibody (ab51032, Abcam, 1:100) and processed for WB analysis
Early to intermediate steps of tumor embolic formation involve specific proteolytic processing of E-cadherin regulated by Rab7
Ye, Gao, Tian et al
Mol. Cancer Res. (2012) 10 (6), 713-26 DOI: 10.1158/1541-7786.MCR-12-0009
Ye, Gao, Tian et al
Mol. Cancer Res. (2012) 10 (6), 713-26 DOI: 10.1158/1541-7786.MCR-12-0009
Showing 1-2 of 2 papers.
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