SNAP23 (NM_003825) Human Recombinant Protein
SKU
TP301596
Recombinant protein of human synaptosomal-associated protein, 23kDa (SNAP23), transcript variant 1, 20 µg
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 23.2 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_003816 |
| Locus ID | 8773 |
| UniProt ID | O00161 |
| Cytogenetics | 15q15.1-q15.2 |
| RefSeq Size | 2650 |
| RefSeq ORF | 633 |
| Synonyms | HsT17016; SNAP-23; SNAP23A; SNAP23B |
| Summary | Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues. The protein encoded by this gene is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion. Two alternative transcript variants encoding different protein isoforms have been described for this gene. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins, Membrane Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | SNARE interactions in vesicular transport |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "SNAP23" proteins (6)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301596 | SNAP23 MS Standard C13 and N15-labeled recombinant protein (NP_003816) | 10 ug |
$3,360.00
|
|
| LC401266 | Lyophilized SNAP23 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC408951 | Lyophilized SNAP23 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY401266 | Transient overexpression lysate of synaptosomal-associated protein, 23kDa (SNAP23), transcript variant 1 (as WB positive control) | 100 ug |
$436.00
|
|
| LY408951 | Transient overexpression lysate of synaptosomal-associated protein, 23kDa (SNAP23), transcript variant 2 (as WB positive control) | 100 ug |
$436.00
|
|
| TP761961 | Purified recombinant protein of Human synaptosomal-associated protein, 23kDa (SNAP23), transcript variant 2,full length, with N-terminal GST and C-terminal His tag, expressed in E. coli, 50ug | 50 ug |
$270.00
|
|
Citations
Development and Validation of Diagnostic Models for Transcriptomic Signature Genes for Multiple Tissues in Osteoarthritis
Gao, Ma, Shao et al
JIR (2024) Volume 17, 5113-5127 DOI: 10.2147/JIR.S472118
Gao, Ma, Shao et al
JIR (2024) Volume 17, 5113-5127 DOI: 10.2147/JIR.S472118
AI Summary: OriGene's DAB (ZLI-9018) was utilized in this study for chromogenic detection during immunohistochemical analysis to visualize transcriptomic signature genes in multiple tissues affected by osteoarthritis.
Snippet: ections were subsequently blocked with goat serum (AR1009;Boster). Primary and secondary antibodies were then incubated sequentially. DAB (ZLI-9018, Origene) was used for chromogenic detection, and hematoxylin (G1004, Servicebio) was used for nuclear staining
SKA2 regulated hyperactive secretory autophagy drives neuroinflammation-induced neurodegeneration
Hartmann, Bajaj, Otten et al
Nat Commun (2024) 15 (1), 2635 DOI: 10.1038/s41467-024-46953-x
Hartmann, Bajaj, Otten et al
Nat Commun (2024) 15 (1), 2635 DOI: 10.1038/s41467-024-46953-x
Cited by 33
AI Summary: OriGene products—specifically Syntaxin3-DDK (TP300658), SNAP29-DDK (TP302179), Syntaxin4 (TP300347), SNAP23-DDK (TP301596), and SEC22B-HIS (AR50533PU-S)—were used as purified recombinant proteins in binding assays to investigate the molecular mechanisms underlying secretory autophagy in neuroinflammation-mediated neurodegeneration.
Snippet: o bovine serum albumin (BSA)- blocked anti-His or anti-Flag-conjugated protein G Dynabeads (Invitrogen, 100-03D, HIS Cell Signaling Technology, #12698, FLAG M2, Sigma, F3165). Purified Syntaxin3-DDK (Origene, TP300658), SNAP29-DDK (Origene, TP302179), Syntaxin4 (Origene, TP300347), SNAP23-DDK (Origene, TP301596) or correspondingly SEC22B-HIS (Origene, AR50533PU-S) (100 ng) was used for the bindi
Showing 1-2 of 2 papers.
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