CDK4 (NM_000075) Human Recombinant Protein
$737.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-Myc/DDK |
| Predicted MW | 33.5 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000066 |
| Locus ID | 1019 |
| UniProt ID | P11802 |
| Cytogenetics | 12q14.1 |
| RefSeq Size | 2020 |
| RefSeq ORF | 909 |
| Synonyms | CMM3; PSK-J3 |
| Summary | The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. provided by RefSeq, Jul 2008 |
| Protein Categories | Cancer: Brain and CNS, Cancer: Gynecologic, Cancer: Skin, Enzyme: Kinases, Intracellular Proteins |
| Protein Families | Druggable Genome, Protein Kinase |
| Protein Pathways | Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer, T cell receptor signaling pathway, Tight junction |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "CDK4" proteins (3)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH301156 | CDK4 MS Standard C13 and N15-labeled recombinant protein (NP_000066) | 10 ug |
$3,360.00
|
|
| LC400021 | Lyophilized CDK4 HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400021 | Transient overexpression lysate of cyclin-dependent kinase 4 (CDK4) (as WB positive control) | 100 ug |
$436.00
|
|
Citations
RPRM negatively regulates ATM levels through its nuclear translocation on irradiation mediated by CDK4/6 and IPO11
Zhang, Ou, Ye et al
iScience (2022) 25 (10), 105115 DOI: 10.1016/j.isci.2022.105115
Zhang, Ou, Ye et al
iScience (2022) 25 (10), 105115 DOI: 10.1016/j.isci.2022.105115
Cited by 8
AI Summary: In this study, OriGene's purified recombinant CDK4 (TP301156) and CDK6 (TP327978) proteins were used to investigate the role of CDK4/6-mediated phosphorylation in regulating RPRM nuclear translocation and its subsequent effect on ATM protein levels.
Snippet: ciclib (Palb) Selleck S15791 Protein G-Agarose Beyotime P2055-2mL Puromycin Beyotime ST551-50mg Purified RPRM peptides (77–109) ChinaPeptides N/A Purified recombinant CDK4 Origene TP301156 Purified recombinant CDK6 Origene TP327978 ------------------------- Critical commercial assays ------------------------- Commet assay kit Trevigen 4250-050-K
Showing 1-1 of 1 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
Related Products
- Price:
- Actual Price:
Welcome to OriGene AI!
I'm your AI-powered guide to everything OriGene.
Ask me anything:
- Product specs
- Ordering help
- Technical questions
- How to find exactly what your experiment needs
Prefer a live agent? Connect with us by clicking the green chat icon, as seen in the image below or email our team at custsupport@origene.com.
