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G protein alpha S (GNAS) (NM_000516) Human Mass Spec Standard

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SKU
PH314197
GNAS MS Standard C13 and N15-labeled recombinant protein (NP_000507)
Size:
10 ug
  $3,360.00
3 Weeks*
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Frequently Bought Together (2)

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Other products for "G protein alpha S or NM_000516"

Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC214197
Predicted MW 45.5 kDa
Protein Sequence
Protein Sequence
RC214197
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_000507
RefSeq Size 1593
RefSeq ORF 1182
Synonyms AHO; C20orf45; GNAS1; GPSA; GSA; GSP; NESP; PITA3; POH; SCG6; SgVI
Locus ID 2778
UniProt ID P63092
Cytogenetics 20q13.32
Summary This locus has a highly complex imprinted expression pattern. It gives rise to maternally, paternally, and biallelically expressed transcripts that are derived from four alternative promoters and 5' exons. Some transcripts contain a differentially methylated region (DMR) at their 5' exons, and this DMR is commonly found in imprinted genes and correlates with transcript expression. An antisense transcript is produced from an overlapping locus on the opposite strand. One of the transcripts produced from this locus, and the antisense transcript, are paternally expressed noncoding RNAs, and may regulate imprinting in this region. In addition, one of the transcripts contains a second overlapping ORF, which encodes a structurally unrelated protein - Alex. Alternative splicing of downstream exons is also observed, which results in different forms of the stimulatory G-protein alpha subunit, a key element of the classical signal transduction pathway linking receptor-ligand interactions with the activation of adenylyl cyclase and a variety of cellular reponses. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene result in pseudohypoparathyroidism type 1a, pseudohypoparathyroidism type 1b, Albright hereditary osteodystrophy, pseudopseudohypoparathyroidism, McCune-Albright syndrome, progressive osseus heteroplasia, polyostotic fibrous dysplasia of bone, and some pituitary tumors. provided by RefSeq, Aug 2012
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Calcium signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Long-term depression, Melanogenesis, Taste transduction, Vascular smooth muscle contraction, Vibrio cholerae infection
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Other "G protein alpha S" proteins (15)
SKU Description Size Price
PH314318 GNAS MS Standard C13 and N15-labeled recombinant protein (NP_536351) 10 ug
$3,360.00
PH316883 GNAS MS Standard C13 and N15-labeled recombinant protein (NP_001070957) 10 ug
$3,360.00
LC402577 Lyophilized GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC409171 Lyophilized GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC421439 Lyophilized GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC421440 Lyophilized GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC424674 Lyophilized GNAS HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY402577 Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 4 (as WB positive control) 100 ug
$436.00
LY409171 Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 3 (as WB positive control) 100 ug
$436.00
LY421439 Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 6 (as WB positive control) 100 ug
$436.00
LY421440 Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 7 (as WB positive control) 100 ug
$436.00
LY424674 Transient overexpression lysate of GNAS complex locus (GNAS), transcript variant 1 (as WB positive control) 100 ug
$436.00
TP314197 Recombinant protein of human GNAS complex locus (GNAS), transcript variant 1, 20 µg 20 ug
$737.00
TP314318 Recombinant protein of human GNAS complex locus (GNAS), transcript variant 3, 20 µg 20 ug
$737.00
TP316883 Purified recombinant protein of Homo sapiens GNAS complex locus (GNAS), transcript variant 7, 20 µg 20 ug
$737.00

file-alt Citations

Anti-tubulin-α-1C autoantibody in systemic lupus erythematosus: a novel indicator of disease activity and vasculitis manifestations
Zhao, Cheng, Gan et al
Clin. Rheumatol. (2018)
AI Summary: OriGene's recombinant tubulin-α-1C protein was used as the coating antigen in ELISA assays to detect anti-tubulin-α-1C autoantibodies, enabling the study to identify this novel biomarker in systemic lupus erythematosus patients.
Snippet: Briefly, 96-well polysorp plates (NUNC, Denmark) were coated with recombinant tubulin-α-1c protein (Origene, Beijing, China) at a concentration of 10 μg/ml in 0.25% glutaraldehyde in phosphate-buffered saline (PBS) at 4 °C overnight
Showing 1-1 of 1 papers.
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