MSH2 (NM_000251) Human Mass Spec Standard

SKU
PH305848
MSH2 MS Standard C13 and N15-labeled recombinant protein (NP_000242)
  $3,360.00
3 Weeks*
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Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC205848
Predicted MW 104.7 kDa
Protein Sequence
Protein Sequence
>RC205848 protein sequence
Red=Cloning site Green=Tags(s)

MAVQPKETLQLESAAEVGFVRFFQGMPEKPTTTVRLFDRGDFYTAHGEDALLAAREVFKTQGVIKYMGPA
GAKNLQSVVLSKMNFESFVKDLLLVRQYRVEVYKNRAGNKASKENDWYLAYKASPGNLSQFEDILFGNND
MSASIGVVGVKMSAVDGQRQVGVGYVDSIQRKLGLCEFPDNDQFSNLEALLIQIGPKECVLPGGETAGDM
GKLRQIIQRGGILITERKKADFSTKDIYQDLNRLLKGKKGEQMNSAVLPEMENQVAVSSLSAVIKFLELL
SDDSNFGQFELTTFDFSQYMKLDIAAVRALNLFQGSVEDTTGSQSLAALLNKCKTPQGQRLVNQWIKQPL
MDKNRIEERLNLVEAFVEDAELRQTLQEDLLRRFPDLNRLAKKFQRQAANLQDCYRLYQGINQLPNVIQA
LEKHEGKHQKLLLAVFVTPLTDLRSDFSKFQEMIETTLDMDQVENHEFLVKPSFDPNLSELREIMNDLEK
KMQSTLISAARDLGLDPGKQIKLDSSAQFGYYFRVTCKEEKVLRNNKNFSTVDIQKNGVKFTNSKLTSLN
EEYTKNKTEYEEAQDAIVKEIVNISSGYVEPMQTLNDVLAQLDAVVSFAHVSNGAPVPYVRPAILEKGQG
RIILKASRHACVEVQDEIAFIPNDVYFEKDKQMFHIITGPNMGGKSTYIRQTGVIVLMAQIGCFVPCESA
EVSIVDCILARVGAGDSQLKGVSTFMAEMLETASILRSATKDSLIIIDELGRGTSTYDGFGLAWAISEYI
ATKIGAFCMFATHFHELTALANQIPTVNNLHVTALTTEETLTMLYQVKKGVCDQSFGIHVAELANFPKHV
IECAKQKALELEEFQYIGESQGYDIMEPAAKKCYLEREQGEKIIQEFLSKVKQMPFTEMSEENITIKLKQ
LKAEVIAKNNSFVNEIISRIKVTT

TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_000242
RefSeq Size 3226
RefSeq ORF 2802
Synonyms COCA1; FCC1; hMSH2; HNPCC; HNPCC1; LCFS2; MMRCS2
Locus ID 4436
UniProt ID P43246
Cytogenetics 2p21-p16.3
Summary This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Apr 2012
Protein Families Druggable Genome, Stem cell - Pluripotency
Protein Pathways Colorectal cancer, Mismatch repair, Pathways in cancer
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Other "MSH2" proteins (5)
SKU Description Size Price
LC424843 Lyophilized MSH2 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY424843 Transient overexpression lysate of mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2) (as WB positive control) 100 ug
$436.00
TP305848 Recombinant protein of human mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), 20 µg 20 ug
$737.00
TP762320 Purified recombinant protein of Human mutS homolog 2, colon cancer, nonpolyposis type 1 (E.coli) (MSH2), Tyr815-Asn920, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$260.00
TP762365 Purified recombinant protein of Human mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli) (MSH2), Tyr121-Ile169-GGGGS-Pro837-Lys907, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$260.00

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