Twist (TWIST1) (NM_000474) Human Mass Spec Standard

SKU
PH302920
TWIST1 MS Standard C13 and N15-labeled recombinant protein (NP_000465)
  $3,360.00
3 Weeks*
Bulk/Customize
Specifications
Specifications
Product Data
Tag C-Myc/DDK
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC202920
Predicted MW 21 kDa
Protein Sequence
Protein Sequence
>Peptide sequence encoded by RC202920
Blue=ORF Red=Cloning site Green=Tag(s)

MMQDVSSSPVSPADDSLSNSEEEPDRQQPPSGKRGGRKRRSSRRSAGGGAGPGGAAGGGVGGGDEPGSP
AQGKRGKKSAGCGGGGGAGGGGGSSSGGGSPQSYEELQTQRVMANVRERQRTQSLNEAFAALRKIIPTL
PSDKLSKIQTLKLAARYIDFLYQVLQSDELDSKMASCSYVAHERLSYAFSVWRMEGAWSMSASH

SGPTRTRPLEQKLISEEDLAANDILDYKDDDDKV

Recombinant protein using RC202920 also available, TP302920
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Storage Store at -80°C. Avoid repeated freeze-thaw cycles.
Stability Stable for 3 months from receipt of products under proper storage and handling conditions.
Shipping Dry Ice
Reference Data
RefSeq NP_000465
RefSeq Size 1669
RefSeq ORF 606
Synonyms ACS3; bHLHa38; BPES2; BPES3; CRS; CRS1; CSO; SCS; SWCOS; TWIST
Locus ID 7291
UniProt ID Q15672
Cytogenetics 7p21.1
Summary This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism. provided by RefSeq, Jul 2020
Protein Families Druggable Genome
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Other "Twist" proteins (3)
SKU Description Size Price
LC424701 Lyophilized TWIST1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY424701 Transient overexpression lysate of twist homolog 1 (Drosophila) (TWIST1) (as WB positive control) 100 ug
$436.00
TP302920 Recombinant protein of human twist homolog 1 (Drosophila) (TWIST1), 20 µg 20 ug
$737.00

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