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CED6 (GULP1) Human Gene Knockout Kit (CRISPR)

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SKU
KN221580
GULP1 - human gene knockout kit via CRISPR, HDR mediated
  $1,657.00
4 Weeks*

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Other products for "CED6 or NM_001252668"

Specifications
Specifications
Product Data
Format 2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Vector GFP-puro
Target Symbol CED6
Locus ID 51454
Components

KN221580G1, CED6 gRNA vector 1 in pCas-Guide CRISPR vector, Target Sequence: AGCAGGAAGAAAGGTAAGTG

KN221580G2, CED6 gRNA vector 2 in pCas-Guide CRISPR vector, Target Sequence: AACTTCATTTCTGGGCCAGG

KN221580D, donor DNA containing left and right homologous arms and GFP-puro functional cassette.

Homologous arm and GFP-puro sequences:

pUC vector backbone in gray; Left arm sequence in blue; GFP-puro in green; Right arm in violet

CTAAGACAAA GATTGTAGCT AATATCTTCT GAGCTCAATA TGTACCAAAT ACTGTGCCAA GTACTTTCAT ACCTTTCCTA ATGTGTAAAA CAATCTTAAG TGGTAGGTAA TTTTATCCTA TGTTTTAACC ACTGCTCCTA GTATATCACC TGTCTTTGTG ACTTTGTAAT AAACACGAAA CTCTTCTGGG CCTCAGGTAA ATAAAAAGTA AAGTGTTTAT ATACACACCT CTTGTCAACA AGCTGAGGAA AAAGTATTGA TCTTTCTTCT CCTTAAGTTT GCAAATAAAT ATAGTTAATG ATGGATATAT AATAGAAAAA AGACAAAATT GAAGAACTTG GGAGGAATTT CTGTGAGACA TTCCTATCTG CTTGTGCCAC TCACGTTATT AAGTACTTGT GTTTTTTCTT ACCCAATGTC CTTTGAGGCA TTTTAGAATA TTGTTTGTAA ATATTTTTAA AAATTTAAAA AGCCTTTATA ATTAAAACCA CATTAGCAAA AGAGAGGTCA GTCAACAGTC CTTTGTTTAT GTTTTAATAT TTTGTCACTT TTACAGGATT TAAGTCGTGG AACTGAACAT TTATTTGGCT GATCCTCATC AAATCTGCAA ACGTTGCTAA TTAGCTTTCC TTAGTTATCA CCCTAGTGAA AGATCAAAGT TGTTTATTAC ACTGAGTTCA CAATACATAT GTGATAATAT GTCGCCTGGC AACTTGAAGC TTGTTGTGAA ATTGCAAAGA ATAAAATGAT CTGAAACTTT GTCCTAACTT TAGCTTATGT AGCCATATAA TACTAAATTC CCTGGGCTTA CATAAGATTA TGGTAACATA AATTCATTCA TAATTGTGTG TGTGTGTGTG CACAGGCTTC ATGTATCATT GAACAATATG TGAGGATTGG TAGTAGATAG ATTGAAAGCA ATGAGGCCAC AATAAGTTTG TTATTAATTT TTAGGTAGGA ATTTAAATAA CTACGAATGT AGTATATTAT AGTGATCACT ATAGGACTGA AAGAAACAGC TAGTTAGATG TTGTTTTTTA ATGGGCAGAA AAACATGGCA TTTGACAAAC TATTTTATGA TGCACTTATA AAGAAAGATA GAAAAATAAA TATAACTTTG CGTAGGTCAG TGAAGTTTAA ATAATGTATC CTTTCCATTC TCAAAGGAGT TCTCTAGTGG AGAGCATGGG GCTCTCTCCT

GE100003, scramble sequence in pCas-Guide vector
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001252668, NM_001252669, NM_016315, NR_045562, NR_045563
UniProt ID Q9UBP9
Synonyms CED-6; CED6; GULP
Summary The protein encoded by this gene is an adapter protein necessary for the engulfment of apoptotic cells by phagocytes. Several transcript variants, some protein coding and some thought not to be protein coding, have been found for this gene. provided by RefSeq, Nov 2011
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Documents
Resources
Other Versions
SKU Description Size Price
GA109815 GULP1 CRISPRa kit - CRISPR gene activation of human GULP PTB domain containing engulfment adaptor 1 1 kit
$1,657.00
KN221580BN GULP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221580LP GULP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN221580RB GULP1 - human gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN421580 GULP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

GULP1 regulates the NRF2-KEAP1 signaling axis in urothelial carcinoma
Hayashi, Guida, Inokawa et al
Sci Signal (2020) 13 (645) DOI: 10.1126/scisignal.aba0443
Cited by 41
AI Summary: OriGene products contributed to this study by providing GULP1 shRNA (Cat# TL312373) and GULP1 cDNA (Cat# RC209587), which were used to manipulate GULP1 expression and investigate its regulatory role in the KEAP1-NRF2 signaling axis in urothelial carcinoma.
Snippet: …Therefore, further exploration of the GULP1-NRF2-KEAP1 signaling axis is needed to evaluate its roles in tumorigenesis. … Our immunohistochemistry results showed differential expression patterns of GULP1 in different layers of cells. The basal part of the epithelium showed no GULP1 expression, in contrast to the luminal layer. The expression pattern of GULP1 in basal and luminal layers was inversely correlated with promoter hypermethylation. …
Showing 1-1 of 1 papers.
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