Mouse Dmrt1i activation kit by CRISPRa
Specifications
| Product Data | |
| Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
|---|---|
| Target Symbol | Dmrt1i |
| Locus ID | 100579137 |
| Components |
GA219614G1, Dmrt1i gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA219614G2, Dmrt1i gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA219614G3, Dmrt1i gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
| OTI Disclaimer | These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc. |
| Shipping | Ambient |
| Reference Data | |
| RefSeq | NR_102372, NR_102373, NR_102374 |
| Summary | This gene is involved in trans-splicing (PMID 20816665) with a functional gene on chromosome 19, Dmrt1 (Dsx- and Mab3-related transcription factor-1), which plays a role in male sexual development. Dmr mainly forms the 3' UTR in the resulting transcript and provides a stop codon, resulting in a truncated Dmrt1 protein. Trans-splicing involving this gene is suggested to serve as a mechanism of negative regulation of Dmrt1 function. Alternative splicing of this gene results in multiple transcript variants. provided by RefSeq, Mar 2013 |
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