Mouse Myo3b activation kit by CRISPRa

SKU GA216738

Myo3b CRISPRa kit - CRISPR gene activation of mouse myosin IIIB

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Myo3b
• Locus ID: 329421
• Components:

  GA216738G1, Myo3b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA216738G2, Myo3b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA216738G3, Myo3b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001042509, NM_177376
• UniProt ID: Q1EG27
• Synonyms: A430065P19Rik
• Summary: Probable actin-based motor with a protein kinase activity (By similarity). Required for normal cochlear hair bundle development and hearing. Plays an important role in the early steps of cochlear hair bundle morphogenesis. Influences the number and lengths of stereocilia to be produced and limits the growth of microvilli within the forming auditory hair bundles thereby contributing to the architecture of the hair bundle, including its staircase pattern (PubMed:26754646). Involved in the elongation of actin in stereocilia tips by transporting the actin regulatory factor ESPN to the plus ends of actin filaments (PubMed:22264607).[UniProtKB/Swiss-Prot Function]