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Mouse Dennd1b activation kit by CRISPRa

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SKU
GA216728
Dennd1b CRISPRa kit - CRISPR gene activation of mouse DENN/MADD domain containing 1B
  $1,657.00
4 Weeks*

Other products for "Dennd1b"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Dennd1b
Locus ID 329260
Components

GA216728G1, Dennd1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA216728G2, Dennd1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA216728G3, Dennd1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001166501, NM_181347, NM_183217
UniProt ID Q3U1T9
Synonyms 4632404N19Rik; 4930467M19Rik; 6820401H01Rik; F730008N07Rik
Summary Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN504488 Dennd1b - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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