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Mouse Atp11c activation kit by CRISPRa

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SKU
GA216592
Atp11c CRISPRa kit - CRISPR gene activation of mouse ATPase, class VI, type 11C
  $1,657.00
4 Weeks*

Other products for "Atp11c"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Atp11c
Locus ID 320940
Components

GA216592G1, Atp11c gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA216592G2, Atp11c gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA216592G3, Atp11c gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001001798, NM_001037863, NM_001359002
UniProt ID Q9QZW0
Synonyms A330005H02Rik; AI315324; Ig
Summary Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. In the cell membrane of erythrocytes, it is required to maintain phosphatidylserine (PS) in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for splenic macrophages (By similarity). Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate phosphatidylserine (PS) flipping in pro-B cells (PubMed:21423172). May be involved in the transport of cholestatic bile acids (PubMed:21518881).UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN501761 Atp11c - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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