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Mouse Mdc1 activation kit by CRISPRa

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SKU
GA214902
Mdc1 CRISPRa kit - CRISPR gene activation of mouse mediator of DNA damage checkpoint 1
  $1,657.00
4 Weeks*

Other products for "Mdc1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Mdc1
Locus ID 240087
Components

GA214902G1, Mdc1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA214902G2, Mdc1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA214902G3, Mdc1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001010833
UniProt ID Q5PSV9
Synonyms 6820401C03; AA413496; mKIAA0170; Nfbd1
Summary The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 7 divergent copies of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci. Mice with mutations in this gene exhibit growth retardation, male infertility, immune defects, chromosome instability, DNA repair defects, and radiation sensitivity. provided by RefSeq, Jul 2008
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Documents
Resources
Other Versions
SKU Description Size Price
KN509899 Mdc1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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