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Mouse Insig1 activation kit by CRISPRa

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SKU
GA214235
Insig1 CRISPRa kit - CRISPR gene activation of mouse insulin induced gene 1
  $1,657.00
4 Weeks*

Other products for "Insig1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Insig1
Locus ID 231070
Components

GA214235G1, Insig1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA214235G2, Insig1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA214235G3, Insig1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_153526
UniProt ID Q8BGI3
Synonyms 1810013C12Rik; Insig-1
Summary Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Initiates the sterol-mediated ubiquitin-mediated endoplasmic reticulum-associated degradation (ERAD) of HMGCR via recruitment of the reductase to the ubiquitin ligase, AMFR/gp78. May play a role in growth and differentiation of tissues involved in metabolic control. May play a regulatory role during G0/G1 transition of cell growth.UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN508357 Insig1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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