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Mouse Bmp3 activation kit by CRISPRa

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SKU
GA212279
Bmp3 CRISPRa kit - CRISPR gene activation of mouse bone morphogenetic protein 3
  $1,657.00
4 Weeks*

Other products for "Bmp3"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Bmp3
Locus ID 110075
Components

GA212279G1, Bmp3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA212279G2, Bmp3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA212279G3, Bmp3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_173404
UniProt ID Q8BHE5
Synonyms 9530029I04Rik
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein suppresses osteoblast differentiation, and negatively regulates bone density, by modulating TGF-beta receptor availability to other ligands. Homozygous knockout mice for this gene exhibit increased bone density and volume, while overexpression of this gene in a transgenic mouse causes bone defects resulting in spontaneous rib fractures. This gene encodes distinct protein isoforms that may be similarly proteolytically processed. provided by RefSeq, Jul 2016
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Documents
Resources
Other Versions
SKU Description Size Price
KN502196 Bmp3 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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