Mouse Topors activation kit by CRISPRa

SKU GA211911

Topors CRISPRa kit - CRISPR gene activation of mouse topoisomerase I binding, arginine/serine-rich

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Topors
• Locus ID: 106021
• Components:

  GA211911G1, Topors gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA211911G2, Topors gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA211911G3, Topors gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_134097
• UniProt ID: Q80Z37
• Synonyms: AW105885; LUN; p53BP3/LUN; TP53BPL
• Summary: Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation.[UniProtKB/Swiss-Prot Function]