Mouse Myh10 activation kit by CRISPRa

SKU GA210773

Myh10 CRISPRa kit - CRISPR gene activation of mouse myosin, heavy polypeptide 10, non-muscle

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Myh10
• Locus ID: 77579
• Components:

  GA210773G1, Myh10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210773G2, Myh10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210773G3, Myh10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_175260
• UniProt ID: Q61879
• Synonyms: 5730504C04Rik; 9330167F11Rik; Fltn; mKIAA3005; Myhn-2; Myhn2; NMHC-B; NMHC II-B; NMHCII-B
• Summary: Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity). Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.[UniProtKB/Swiss-Prot Function]