Mouse Nhej1 activation kit by CRISPRa

SKU GA210267

Nhej1 CRISPRa kit - CRISPR gene activation of mouse non-homologous end joining factor 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nhej1
• Locus ID: 75570
• Components:

  GA210267G1, Nhej1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA210267G2, Nhej1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA210267G3, Nhej1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_029342
• UniProt ID: Q3KNJ2
• Synonyms: 1700029B21Rik; cernunnos; XLF
• Summary: DNA repair protein involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. May serve as a bridge between XRCC4 and the other NHEJ factors located at DNA ends, or may participate in reconfiguration of the end bound NHEJ factors to allow XRCC4 access to the DNA termini. It may act in concert with XRCC6/XRCC5 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are noncomplementary or partially complementary (PubMed:17360556). Binds DNA in a length-dependent manner (By similarity).[UniProtKB/Swiss-Prot Function]