Mouse Pnpla2 activation kit by CRISPRa

SKU GA206990

Pnpla2 CRISPRa kit - CRISPR gene activation of mouse patatin-like phospholipase domain containing 2

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Pnpla2
• Locus ID: 66853
• Components:

  GA206990G1, Pnpla2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA206990G2, Pnpla2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA206990G3, Pnpla2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001163689, NM_025802, NR_028142
• UniProt ID: Q8BJ56
• Synonyms: 0610039C21Rik; 1110001C14Rik; Atgl; TTS-2.2
• Summary: Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets (PubMed:15550674). Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.[UniProtKB/Swiss-Prot Function]