Mouse Oas1b activation kit by CRISPRa

SKU GA204835

Oas1b CRISPRa kit - CRISPR gene activation of mouse 2'-5' oligoadenylate synthetase 1B

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Oas1b
• Locus ID: 23961
• Components:

  GA204835G1, Oas1b gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204835G2, Oas1b gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204835G3, Oas1b gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001083925, NM_011853, NR_003507
• UniProt ID: Q60856
• Synonyms: Flv; L1; Mmu-L1; Oas1; Oias-2; Oias2; Wnv
• Summary: This gene is a member of the 2'-5' oligoA synthetase family, which are clustered on chromosome 5. The encoded protein functions in the interferon-regulated OAS/RNase L system, which mediates RNA decay as part of the innate antiviral immunity pathway. The protein binds double-stranded RNA and oligomerizes ATP, which activate the single-stranded RNA cleavage enzyme RNase L. This protein mediates resistance to flaviviruses such as West Nile virus. The majority of wild mouse strains produce a functional protein and are resistant to flavivirus infection, whereas some inbred mouse strains including the strain of the reference genome, C57BL/6J, contain a premature stop codon that inactivates this gene product. [provided by RefSeq, Jul 2008]