Mouse Tfec activation kit by CRISPRa

SKU GA204250

Tfec CRISPRa kit - CRISPR gene activation of mouse transcription factor EC

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Tfec
• Locus ID: 21426
• Components:

  GA204250G1, Tfec gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204250G2, Tfec gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204250G3, Tfec gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_031198
• UniProt ID: Q9WTW4
• Synonyms: BB107417; bHLHe34; Tcfec
• Summary: Transcriptional regulator that acts as a repressor or an activator. Acts as a transcriptional transactivator on the proximal promoter region of the tartrate-resistant acid phosphatase (TRAP) E-box containing promoter. Collaborates with MITF in target gene activation. Acts as a transcriptional repressor on minimal promoter containing element F (that includes an E-box sequence) (By similarity). Binds to element F in an E-box sequence-specific manner (By similarity). Acts as a transcriptional repressor on minimal promoter containing mu E3 enhancer sequence (By similarity). Binds to mu E3 DNA sequence of the immunoglobulin heavy-chain gene enhancer (By similarity). Binds DNA in a homo- or heterodimeric form.[UniProtKB/Swiss-Prot Function]