Mouse Tcf3 activation kit by CRISPRa

SKU GA204248

Tcf3 CRISPRa kit - CRISPR gene activation of mouse transcription factor 3

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Tcf3
• Locus ID: 21423
• Components:

  GA204248G1, Tcf3 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA204248G2, Tcf3 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA204248G3, Tcf3 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001164147, NM_001164148, NM_001164149, NM_001164150, NM_001164151, NM_001164152, NM_001164153, NM_011548
• UniProt ID: P15806
• Synonyms: A1; AA408400; ALF2; AW209082; bHLHb21; E2A; E12; E12/E47; E47; KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a
• Summary: Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region.[UniProtKB/Swiss-Prot Function]