Mouse Frzb activation kit by CRISPRa

SKU GA203854

Frzb CRISPRa kit - CRISPR gene activation of mouse frizzled-related protein

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Frzb
• Locus ID: 20378
• Components:

  GA203854G1, Frzb gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA203854G2, Frzb gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA203854G3, Frzb gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_011356
• UniProt ID: P97401
• Synonyms: frezzled; fritz; Frp; frzb-1; Sfrp3
• Summary: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development (By similarity).[UniProtKB/Swiss-Prot Function]