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Mouse Pvt1 activation kit by CRISPRa

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SKU
GA203511
Pvt1 CRISPRa kit - CRISPR gene activation of mouse Pvt1 oncogene
  $1,657.00
4 Weeks*

Other products for "Pvt1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Pvt1
Locus ID 19296
Components

GA203511G1, Pvt1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA203511G2, Pvt1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA203511G3, Pvt1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NR_003368, NR_132746, NR_132747, NM_011222
Summary This gene produces a long non-coding RNA that has been identified as a candidate oncogene. In humans, increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Consistently, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. In mouse, this gene has also been found to be a potential regulator of cardiac hypertrophy. Alternative splicing results in multiple transcript variants. provided by RefSeq, Sep 2015
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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