Mouse Nxn activation kit by CRISPRa

SKU GA202997

Nxn CRISPRa kit - CRISPR gene activation of mouse nucleoredoxin

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Nxn
• Locus ID: 18230
• Components:

  GA202997G1, Nxn gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA202997G2, Nxn gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA202997G3, Nxn gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_008750
• UniProt ID: P97346
• Synonyms: l11Jus13
• Summary: Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A).[UniProtKB/Swiss-Prot Function]