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Mouse Ngf activation kit by CRISPRa

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SKU
GA202896
Ngf CRISPRa kit - CRISPR gene activation of mouse nerve growth factor
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

TA328880 Rabbit Polyclonal Anti-mNGF
50 ul
$1,145.00

Other products for "Ngf"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Ngf
Locus ID 18049
Components

GA202896G1, Ngf gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA202896G2, Ngf gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA202896G3, Ngf gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001112698, NM_013609
UniProt ID P01139
Synonyms Ngfb
Summary Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032).UniProtKB/Swiss-Prot Function
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Documents
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Other Versions
SKU Description Size Price
KN310963 Ngf - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310963BN Ngf - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310963LP Ngf - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN310963RB Ngf - mouse gene knockout kit via CRISPR, HDR mediated 1 kit
$1,657.00
KN510963 Ngf - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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