Mouse Hmox1 activation kit by CRISPRa

SKU GA201926

Hmox1 CRISPRa kit - CRISPR gene activation of mouse heme oxygenase 1

Product Data

• Format: 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
• Target Symbol: Hmox1
• Locus ID: 15368
• Components:

  GA201926G1, Hmox1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

  GA201926G2, Hmox1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

  GA201926G3, Hmox1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

  1 CRISPRa-Enhancer vector, SKU GE100056

  1 CRISPRa scramble vector, SKU GE100077

• OTI Disclaimer: These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
• Shipping: Ambient

Reference Data

• RefSeq: NM_010442
• UniProt ID: P14901
• Synonyms: D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32
• Summary: Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.[UniProtKB/Swiss-Prot Function]