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Mouse Cd3e activation kit by CRISPRa

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SKU
GA200622
Cd3e CRISPRa kit - CRISPR gene activation of mouse CD3 antigen, epsilon polypeptide
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

TA385684 Recombinant Anti-CD3 epsilon (Clone 500A2)
200 ug
$770.00

Other products for "Cd3e"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Cd3e
Locus ID 12501
Components

GA200622G1, Cd3e gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA200622G2, Cd3e gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA200622G3, Cd3e gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_007648
UniProt ID P22646
Synonyms AI504783; CD3; CD3epsilon; T3e
Summary Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:19956738, PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN502914 Cd3e - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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