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Mouse Asic1 activation kit by CRISPRa

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SKU
GA200019
Asic1 CRISPRa kit - CRISPR gene activation of mouse acid-sensing (proton-gated) ion channel 1
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

TA326467 Mouse Monoclonal Anti-ASIC1 Antibody
100 ug
$745.00

Other products for "Asic1"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol Asic1
Locus ID 11419
Components

GA200019G1, Asic1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA200019G2, Asic1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA200019G3, Asic1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Shipping Ambient
Reference Data
RefSeq NM_001289791, NM_009597
UniProt ID Q6NXK8
Synonyms Accn2; AI843610; ASIC; ASIC1a; B530003N02Rik; BNaC2
Summary Proton-gated sodium channel; it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear.UniProtKB/Swiss-Prot Function
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Other Versions
SKU Description Size Price
KN501678 Asic1 - KN2.0, Mouse gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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