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Human ATXN7L3B activation kit by CRISPRa

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SKU
GA118622
ATXN7L3B CRISPRa kit - CRISPR gene activation of human ataxin 7 like 3B
  $1,657.00
4 Weeks*

Frequently Bought Together (1)

RC226766 ATXN7L3B (Myc-DDK-tagged)-Human ataxin 7-like 3B (ATXN7L3B)
10 ug
$150.00

Other products for "ATXN7L3B"

Specifications
Specifications
Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Target Symbol ATXN7L3B
Locus ID 552889
Components

GA118622G1, ATXN7L3B gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA118622G2, ATXN7L3B gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA118622G3, ATXN7L3B gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077
OTI Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
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Reference Data
RefSeq NM_001136262, NR_015371
UniProt ID Q96GX2
Synonyms lnc-SCA7
Summary By binding to ENY2, interferes with the nuclear functions of the deubiquitinase (DUB) module of the SAGA complex which consists of ENY2, ATXN7, ATXN7L3 and the histone deubiquitinating component USP22. Affects USP22 DUB activity toward histones indirectly by changing the subcellular distribution of ENY2 and altering ENY2 availability for ATXN7L3 interaction. Regulates H2B monoubiquitination (H2Bub1) levels through cytoplasmic sequestration of ENY2 resulting in loss of nuclear ENY2-ATXN7L3 association which destabilizes ATXN7L3. Affects protein expression levels of ENY2 and ATXN7L3.UniProtKB/Swiss-Prot Function
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Documents
Resources
Other Versions
SKU Description Size Price
KN426766 ATXN7L3B - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. 1 kit
$1,657.00

file-alt Citations

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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